Synthesis and Cytotoxic Evaluation of Fatty Acid Based- Amino Alcohols

In the present investigation, we describe the synthesis of β-amino alcohols from a medium chain fatty acid, 10-undecenoic acid and evaluation of their cytotoxicity. Nucleophilic ring opening reactions of epoxy undecanoates of varying ester chain lengths (C1-C8) with aniline in equimolar ratio (1:1) was carried out using Bronsted acidic ionic liquid, 1methylimidazolium tetrafluoroborate, thus playing a dual role of solvent as well as a reaction medium. The cytotoxic properties of the amino alcohols of 10-undecenoic acid were evaluated. It was observed that the compound 4f showed promising cytotoxicity against HeLa, compound 4a showed good activity against A549 cell line, while compounds 4a, 4c showed good activity against MDA-MB-231 cell line. All other compounds showed moderate activity against all the other tested cell lines.